EFFECT OF COLD EXPOSURE ON THE ACTION OF MORPHINE IN RATS AND MICE,

Abstract

Data are presented showing that cold adaptation diminishes the depressant effects of morphine on respiratory minute volume, oxygen consumption and analgesia on the one hand, but enhances the toxicity of morphine on the other. Attempts to account for the difference in sensitivity between cold adapted and nonadapted animals by measuring the conjugation, excretion, and distribution of morphine in vivo, and by determining its effect on the respiration of KC1-stimulated brain slices in vitro were unsuccessful. (Author)

Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1963
Accession Number
AD0434079

Entities

People

  • E. L. Way
  • H. W. Elliott

Organizations

  • University of California, Los Angeles

Tags

DTIC Thesaurus Topics

  • Analgesia
  • Biological Sciences
  • Excretion
  • Morphine
  • Physiology
  • Respiration
  • Sensitivity
  • Therapy
  • Toxicity

Fields of Study

  • Biology

Readers

  • Cardiovascular Physiology