CUTANEOUS TOXICITY EVALUATION OF AIR FORCE DEVELOPMENT MATERIALS-VI

Abstract

Ten Air Force development materials were studied via the prophetic patch test method on laboratory animals to determine the primary irritant effect, gross sensitization index, and gross percutaneous toxicity of these materials. The patch test studies with rabbits indicated that three of the materials showed very mild primary irritant action. None of the materials produced any sensitization or gross systemic poisoning. Dermal reactions on rabbits were so mild that testing on humans was not precluded. The materials were, therefore, tested on human volunteers by the Shelanski repeated insult patch test. Results of this test indicated that all of the materials were safe to use on contact with human skin.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1964
Accession Number
AD0435776

Entities

People

  • Morris V. Shelanski

Tags

DTIC Thesaurus Topics

  • Air Flow
  • Air Force
  • Air Force Facilities
  • Animals
  • Aqueous Solutions
  • Biomedical Research
  • Contracts
  • Government Procurement
  • Governments
  • Irritants
  • Irritation
  • Laboratory Animals
  • Materials
  • Test Methods
  • Toxic Hazards
  • Toxicity
  • Volunteers

Readers

  • Toxicology/Environmental Toxicology