STUDIES OF ABSORPTION-TRANSPORT MECHANISMS IN THE SMALL INTESTINE.
Abstract
Studies concerning the mechanisms of intestinal glucose absorption indicate that the monophosphoesterases are not distributed along the intestinal length in a pattern which would directly involve them in the absorption process. The kinetics of these phosphatases indicate support for the concept that phosphorylation of glucose is not involved in its transport across the mucosa. The oxygen utilization by in vitro intestinal segments during glucose transport indicates a dependency upon .lycolytic pathways for theincreased energy requirements. Indirect evidence of non-oxidative phosphorylation of ADP to ATP has been presented and has been postulated as the possible rate limiting step in the transport scheme. Ouabain, at concentrations selected to interfere selectively with the sodium pump, reduces glucose absorption but does not alter the oxidative requirements of the absorbing in vitro preparation. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 31, 1964
- Accession Number
- AD0437605
Entities
People
- Arthur S. Nunn Jr.
Organizations
- University of Miami