OBSERVATIONS ON MODE OF ACTION OF ENDOTOXIN IN CHICK EMBRYOS
Abstract
The preu uonfirmed the previous observation of Smith and Thomas that the chick embryo becomes refractory to intravenously administered endotoxin during the period frum the 11th to the 15th day of incubation. The magnitude of the change in susceptibility is greater than 10,000fold. Catecholamines could not be implicated in the lethal action of endotoxin in the chick embryo. Histamine, serotonin and acetylcholine were not highly toxic for the endotoxin- susceptible embryos. An anticoagulant heparin, did not protect against endotoxin, which caused capillary stasis and perivascular hemorrhage in the embryos. Natural antibody against Vibrio cholerae endotoxin could not be detected in the blood during the embryonic state. A marked hypoglycemia resulted following administration of endotoxin and insulin in the younger embryos after a slight delay in the former case.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 18, 1963
- Accession Number
- AD0443546
Entities
People
- Richard A. Finkelstein
Organizations
- Walter Reed Army Institute of Research