BOTULINUM TOXOIDS
Abstract
Procedures were developed for preparing purified aluminum-phosphate-absorbed, univalent, bivalent, and pentavalent botulinum toxoids to immunize man. All preparations were well tolerated and elicited satisfactory antitoxin responses in man, whether administered as a single antigen or in combination. Four separate pentavalent Type ABCDE toxoids produced immune responses to each antigen in a considerable proportion of individuals following an initial series of three injections. A booster injection administered one year after the initial injection markedly increased the antitoxin titers, and measurable antitoxin titers were found in 86 to 100% of the individuals immunized. The toxoids were antigenic for mice, guinea pigs, and rabbits. In guinea pigs the toxoids afforded a high level of resistance to challenge with toxins administered by various routes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1964
- Accession Number
- AD0443673
Entities
People
- Matteo A. Cardella
Organizations
- United States Army Biological Warfare Laboratories