TREATMENT OF HEMOLYTIC ANEMIAS WITH ASSOCIATED INTRACORPUSCULAR DEFECT
Abstract
Anemia by definition is a clinically significant reduction of the red cell mass to levels below normal. It may result from inadequate production of red cells or from decreased life span of the red cells. Hemolytic anemia belongs in the latter category; in all hereditary hemolytic anemias, the short life span of the red cell is a consequence of some intrinsic fault. The cell is faultily constructed in such a way that it is incapable of surviving normally in the normal blood stream. Transfuse the blood from such a patient into a normal recipient and the red cells are quickly destroyed. Transfuse normal red cells into the patient with hereditary spherocytosis and they survive normally. It is the red cell itself, not its environment, that is fundamentally at fault. Yet, fortunately, the environment can sometimes be altered in such a way that even the abnormal red cells survive, and, in spite of the abnormality, the hemolytic disease is corrected.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1964
- Accession Number
- AD0445256
Entities
People
- William H. Crosby
Organizations
- Walter Reed Army Institute of Research