EFFECT OF CORTISONE ON PROTECTION AGAINST RELATED ARBOVIRUSES IN VACCINATED MICE

Abstract

Protection of mice vaccinated with Group A arboviruses against challenges with heterotypic viruses was investigated to determine whether or not resistance is fully manifested prior to challenge, or if such resistance develops as a result of the challenge stimulus. Cortisone acetate was administered intramuscularly in four daily doses of five mg each commencing the day before inoculation of the challenge virus to suppress the immune response to the challenge stimulus. This treatment inhibited protection against Venezuelan equine encephalitis virus (VEE) in mice previously vaccinated with Sindbis virus. Protection against Semliki Forest virus (SF) was partially inhibited by cortisone in mice vaccinated with VEE or Sindbis viruses. Homologous protection in immune mice was essentially unaltered by cortisone treatment. The data suggest that for certain cross-protection systems resistance to heterotypic viruses is manifested in the vaccinated animal as a result of the challenge stimulus.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1964
Accession Number
AD0449730

Entities

People

  • William P. Allen

Organizations

  • United States Army Biological Warfare Laboratories

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Antibodies
  • Arbovirus Infections
  • Arboviruses
  • Biological Laboratories
  • Encephalitis
  • Equine Encephalitis
  • Laboratory Animals
  • Oklahoma
  • Resistance
  • United States
  • Viruses

Fields of Study

  • Biology

Readers

  • Immunology
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology