ACUTE TOXICITY OF ALKYL AND PHENYLALKYLPHOSPHONATES IN THE GUINEA PIG AND RABBIT IN RELATION TO THEIR ANTICHOLINESTERASE ACTIVITY AND THEIR ENZYMATIC INACTIVATION,
Abstract
Rabbits are more susceptible than guinea pigs to the toxic action of alkyl and phenylakylphosphonates. Rabbit red cell cholinesterase is more susceptible than guinea pig red cell cholinesterase to the inactivating action of these compounds. Multiple regression analysis revealed that the variation in the anticholinesterase activity and the ability of the phosphonates to be inactivated by enzymes in rabbit plasma accounted for 86% of the variation in toxicity of these compounds in rabbits. Only 48% of the variation in toxicity could be attributed to the anticholinesterase activity alone. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 31, 1964
- Accession Number
- AD0450499
Entities
People
- Charles L. Punte
- Elmer L. Becker
- J. F. Barbaro
Organizations
- Walter Reed Army Institute of Research