AEROSOL CHALLENGE OF ANIMALS
Abstract
Experimental uses of artificially created aerosols are manifold and are especially important for respiratory disease studies. Because the respiratory route is often the natural means of infection in man, study of the pathogenesis of diseases in animal counterparts is more meaningful if animals also are infected experimentally by the respiratory route. In contrast to intratracheal or intranasal instillation, challenge with air-borne particulates greatly increases test reliability because variables can be better controlled and quantitated. Dosage, aerosol particle size, aerosol age, environmental temperature, and relative humidity can be controlled, measured, and analyzed to a variable degree. Moreovej, additional experimentation can be accomplished to determine host susceptibility to respiratory challenge, estimating or quantitating dose-response curves, testing the effect of therapy or stress, and evaluating the efficiency of aero genic vaccination. However, respiratory exposure appears to be the least understood challenge method in animal experimentation. This manuscript, therefore, surveys and describes the basic, practical techniques required to challenge animals with infectious aerosols artificially produced.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1964
- Accession Number
- AD0450639
Entities
People
- G. Briggs Phillips
- Joseph V. Jemski
Organizations
- United States Army Biological Warfare Laboratories