THE EFFECTS OF X-IRRADIATION ON THE ANTIGENIC CHARACTER OF ANCISTRODON PISCIVORUS (COTTONMOUTH MOCCASIN) VENOM,
Abstract
X-irradiated cottonmouth moccasin venom (Ancistrodon piscivorus) which exhibited reduced local and lethal properties was studied to determine alterations in its antigenic character. Antibody titers of rabbits immunized with X-irradiated venom were compared to those of rabbits immunized with untreated venom. Studies indicated the antisera produced by injections of X-irradiated venom contained 80% of the neutralization titer of antisera produced by untreated venom, and effectively neutralized both the local and lethal effects of untreated venom. Animals immunized with X-irradiated venom suffered no mortality and much less local tissue damage than the group immunized with untreated venom. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 10, 1964
- Accession Number
- AD0455003
Entities
People
- Herschel H. Flowers
Organizations
- United States Army Medical Research Laboratory