THE AMINO- AND CARBOXYL-TERMINAL RESIDUES AND THE SELF-DIGESTION OF BOVINE PANCREATIC CARBOXYPEPTIDASE A,

Abstract

The generic term carboxypeptidase A applies to an enzyme which can be prepared by three different procedures yielding preparations which differ from each other chemically in amino acid composition, in NH2-terminal residues, and in solubility. In the present study, the terminal amino acid residues of each of the preparations were identified. In addition, quantitative data are presented to demonstrate a hitherto undetected heterogeneity in the COOH-terminal region of these enzymes. This heterogeneity involves a single amino acid replacement which probably is an expression of a genetic trait. (Author)

Document Details

Document Type
Technical Report
Publication Date
Jun 11, 1964
Accession Number
AD0455831

Entities

People

  • E. O. P. Thompson
  • Jean-pierre Bargetzi
  • K. S. V. Sampath Kumar
  • Kenneth A. Walsh

Organizations

  • University of Washington

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Chemical Compounds
  • Chemical Synthesis
  • Chemistry
  • Digestive System Processes
  • Heterogeneity
  • Solubility
  • Terminals

Fields of Study

  • Biology

Readers

  • Analytical Chemistry
  • Molecular Genetics
  • Systems Analysis and Design

Technology Areas

  • Biotechnology