IMMUNOGENIC POTENCY OF PASTEURELLA TULARENSIS CELL WALLS
Abstract
Purified cell walls of sonically disrupted viable Pasteurella tularensis strains SCHU S5 and 38A were evaluated for immunogenic properties in the monkey (Macaca mulatta). Subcutaneous vaccination with 12 mg of the larger cell-wall particles (sedimenting at 30,000 x g), either in one site or equally divided among 6 sites, evoked no febrile response, caused few skin lesions, and stimulated a rapid agglutinin response. Protection afforded animals vaccinated with the wall fraction of strain SCHU S5 indicated promise of definition of the sites of the antigens in the cell that are involved in evoking immunity and potential for the preparation of an effective nonviable vaccine.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1965
- Accession Number
- AD0456168
Entities
People
- Maruice L. Guss
Organizations
- United States Army Biological Warfare Laboratories