CARDIAC ANAPHYLAXIS
Abstract
The sensitization process can be separated from the process of antibody uptake. The amount of antibody retained by in vitro sensitized tissues is proportional to the concentration of antibody present in the bulk phase of the solution used for sensitization. Temperature has little effect on the amount of antibody retained by the tissue as a whole but does affect the degree of sensitization achieved. The velocity of sensitization is proportional to the bulk phase concentration of antibody used. Sensitization seems to be associated with the attachment of antibody molecules to very specific locations on sensitizable cells. This attachment process may involve the dissociation of antibody molecules from loose bonds with nonreactive cells and transfer to reactive cells. Experimental results have been presented which show that sensitization is related to the amount of precipitating antibody present in a mixture of antibody and homologous gamma-globulin. In the case of guinea pig atrial tissue, antibody probably is attached to several sites on reactive, histamine-releasing, cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1965
- Accession Number
- AD0463343
Entities
People
- George A. Feigen
- Gerald G. Vurek
Organizations
- Stanford University