ONSET OF COCCIDIOIDOMYCOSIS IN MOUSE LUNG AFTER INTRAVENOUS INJECTION
Abstract
Intravenous injection of mice with a massive dose of Coccidioides immitis fungal elements caused a moderate inflammatory response after 6 hours. It was composed of small focal collections of lymphocytes and neutrophils surrounding the rounded fungal elements in the mouse lungs. No further change was noted at 24 hours. Spherules with endospores varying in diameter from 15 to 40 microns were seen at 48 and 54 hours. Neutrophils persisted throughout this time and increased only minimally; the lymphocytic response was more marked at these later observations.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1965
- Accession Number
- AD0465198
Entities
People
- James T. Sinski
- Peter J. Soto Jr.
Organizations
- United States Army Biological Warfare Laboratories