SUSCEPTIBILITY TO INFECTION IN IRRADIATED ANIMALS
Abstract
Exposure of Swiss albino mice to various levels of Co60 gamma radiation and subsequently to various levels of infection with virulent and avirulent strains of Bacillus anthracis indicates that a significant pronounced combined effect is present. At low levels of radiation, bacterial challenges near the LD50 are necessary to demonstrate the combined effect while at high levels of radiation a few organisms produce a pronounced combined effect. The time interval between radiation and infectious challenge significantly affects the degree of interaction with a 7 day interval resulting in higher mortalities than either a 1 or 3 day interval.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1965
- Accession Number
- AD0465885
Entities
People
- Alan M. Shefner
- Bernard J. Mieszkuc
Organizations
- IIT Research Institute