REJECTION OF ALLOGENEIC SKIN GRAFTS AND PRODUCTION OF ISOHEMAGGLUTININS BY SENSITIZED MICE AFTER SUBLETHAL IRRADIATION.
Abstract
Male B6D2F1 mice were sensitized by the following means: (1) an allogeneic (A/HeJ) skin graft; (2) three s.c. injections of A/HeJ spleen cells in Freund's complete adjuvant; or (3) three i.p. 'njections of A/HeJ spleen cells. One week after the last injection, mice from each group received 670 rad whole-body X radiation. Sera were obtained frequently for hemagglutinin assay, and the mice were grafted with A/HeJ skin 30 days or 61 days after irradiation. In all groups the homograft response was significantly impaired 30 and 61 days after irradiation; however, in groups (1) and (2) normal secondary hemagglutinin responses were noted. This asynchronous recovery of the hemagglutinin and homograft responses suggested that distinct cell populations were responsible for these two manifestations of immunologic reactivity. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- May 27, 1965
- Accession Number
- AD0466883
Entities
People
- Leonard J. Cole
- M. L. Tyan
Organizations
- Naval Radiological Defense Laboratory