EFFECT OF ENZYMATIC FUNCTIONAL GROUP INHIBITORS ON THE ESTERASES OF CROTALUS ATROX VENOM,
Abstract
The activities of phosphodiesterase, phosphomonoesterase and esterase in Crotalus atrox venom can be completely inhibited by one or more of the following enzymatic functional groupspecific reagents: 2-mercaptoethanol, 2,3dimercaptopropanol, p-hydroxymercuibenzoate, iodoacetamide, diisopropylfluorophosphate, ethylenediaminetetraacetic acid, N-bromosuccinimide. Phosphodiesterase was activated by the divalent cations of iron, cobalt, nickel, manganese, zinc and the alkaline earths; phosphomonoesterase was activated by calcium, iron, cobalt and zinc; esterase was not activated by metal ions. In general, the divalent cations of cadmium, mercury and copper inhibited all three enzymes. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 23, 1965
- Accession Number
- AD0466947
Entities
People
- John H. Brown
Organizations
- United States Army Medical Research Laboratory