BASIC BIOLOGY AND TROPISTIC BEHAVIOR OF SCHISTOSOMA MANSONI CERCARIAE RELATING TO CERCARICIDAL AGENTS.

Abstract

Several compounds were studied for repellent activity. Most promising is the oil from seeds of Pterdon pubescens which gave lasting protection against infection, even when diluted to 5% soln. in DMSO or ether. Repellents DEET and Entoral were not effective. Intradermal test for diagnosis was improved and purified materials developed. Techniques were developed to permit large scale culture of snail hosts and cercariae in the laboratory. A number of proposed compounds were tested after development of routine procedures. No correlation between in vitro and in vivo activities. Methods were developed for infection f hamster thru cheek pouch for screening. Studies continue on these problems and on tropistic behavior of cercariae. (Author)

Document Details

Document Type
Technical Report
Publication Date
Jun 30, 1965
Accession Number
AD0467125

Entities

People

  • Jose Pellegrino

Tags

DTIC Thesaurus Topics

  • Biology
  • Buildings And Structures
  • Infection
  • Materials
  • Research Facilities
  • Schistosoma
  • Schistosoma Mansoni
  • Wound Infections

Fields of Study

  • Biology

Readers

  • Marine Ecological Systems Migration
  • Toxicology/Environmental Toxicology
  • Virology (or Medical Virology).