METABOLIC CHANGES IN HUMANS FOLLOWING TOTAL BODY IRRADIATION
Abstract
These studies are designed to obtain information which is necessary to estimate combat effectiveness of troops and to develop methods of diagnosis, prognosis, prophylaxis and treatment of radiation injury. At the present time parameters of active investigation are clinical findings, hematologic effects, profile scores, miscellaneous laboratory tests, deoxycytidine excretion in the urine, xanthurenic acid excretion in the urine, chromosome changes in leucocytes, immunologic studies and the use of autologous bone marrow. Six patients were given from 149r to 231r (100-150 rad) total body irradiation from a Co60 source. Only one of the patients had prodromal nausea and vomiting with nausea lasting 48 hours. The lowest hematologic values were found 25 to 35 days after irradiation. Deoxcytidine was found in increased amounts in the urine from patients after total body irradiation. In rats much larger amounts were found in the urine after 500r and 800r whole body irradiation than after lesser doses. Studies indicate there may be an immunologic post irradiation alteration in human gamma globulin antigenicity. Combat effectiveness would be relatively maintained with an exposure up to 200 rad, though a second exposure would result in significant troop ineffectiveness.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 29, 1964
- Accession Number
- AD0467571
Entities
People
- Ben I. Friedman
- Eugene L. Saenger
- Harold Perry
- James G. Kereiakes
Organizations
- University of Cincinnati