COCCIDIOIDIN SENSITIVITY IN GUINEA PIGS IMMUNIZED WITH KILLED ARTHROSPORES
Abstract
Guinea pigs injected subcutaneously with dead C. immitis arthrospores developed sensitivity to coccidioidin skin testing after 1 1/2 weeks. At that time indurations 5 mm or greater in diameter were seen at 8 and 24 hours. Later indurations, most often with erythema, were observed at 3, 5, 8, 24, and 48 hours. Gross reactions were not completely specific to the immunized animals and one non immunized control animal developed similar indurations. Histologic features of a delayed hypersensitivity also appeared 1 1/2 weeks after immunization. This reaction consisted first of early neutrophilic infiltration of the dermis and subcutaneous tissues uniformly present at 3 hours and less marked by 48 hours. The second cellular feature was a later, variable mononuclear cell infiltration and was usually most marked at 24 and 48 hours. The acute inflammatory reaction was produced in both sensitized and control animals. The two groups differed in the degree of mononuclear cell infiltration, which occurred sooner and was more marked in the sensitized animals than in the control.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1965
- Accession Number
- AD0469391
Entities
People
- Frederic G. Dalldorf
- James T. Sinski
Organizations
- United States Army Biological Warfare Laboratories