ANTHRAX TOXIN: ITS EFFECT ON THE CENTRAL NERVOUS SYSTEM,

Abstract

Anthrax toxin depressed the cerebral cortical electrical activity of both anesthetized and nonanesthetized monkeys. Concurrent recordings on a physiograph recorder revealed changes in their electrocardiogram and anoxic hypertension that progressed with the degree of intoxication to final cardiovascular collapse. Changes in cortical activity were either partial or complete, and in some cases cortical activity was followed by depression in cyclic patterns that appeared independent of the physiological changes. Those animals that died showed a respiratory failure that appeared to be of central origin involving the respiratory center of the brain. Survival with no changes in physiology or cortical activity occurred in monkeys pretreated and post-treated up to 8 hours with specific anthrax antisera. (Author)

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1965
Accession Number
AD0472302

Entities

People

  • Ralph E. Lincoln

Organizations

  • United States Army Biological Warfare Laboratories

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Biological Sciences
  • Brain
  • Central Nervous System
  • Collapse
  • Depression
  • Electrocardiography
  • Health Services
  • Hypertension
  • Immune Serums
  • Intoxication
  • Nervous System
  • Physiology
  • Recording Systems

Fields of Study

  • Biology
  • Medicine
  • Psychology

Readers

  • Cardiovascular Physiology
  • Immunology
  • Neuroscience