NATURAL DRUG RESISTANCE OF HETEROGENEOUS SINGLE CELL TRANSPLANTS
Abstract
Population analysis of a cancer clone derived from a single cancer cell was made, using a clonal transplant-strain of the rat ascites hepatoma, CL- 1-AH-66F. The natural resistance to nitrogen mustard N-oxide and the chromosomal constitution were studied, after establishing subclonal tumors from the original clone CL-1-AH-66F. The results indicated the following facts: (1) The cancer clone is not a uniform but a complex population of cells with different degrees of drug resistance. (2) The degree of drug resistance of the original clone and its subclones varies naturally within a certain range during serial passages of them in compatible hosts. (3) No specific correlation was found between the degree of drug resistance and chromosomal feature of the subclones. (4) It was suggested that the variation in drug resistance of cancer clone is not always associated to the genetic heterogeneity of cells in the cancer clone.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 29, 1965
- Accession Number
- AD0474986
Entities
People
- Tomizo Yoshida