FACTORS AFFECTING RESPONSES OF WHITE CARNEAU PIGEONS TO RESPIRATORY DOSES OF VEE VIRUS
Abstract
The ability of Venezuelan equine encephalitis (VEE) virus to induce viremia and elicit formation of serum neutralizing antibodies was studied in White Carneau pigeons. Among birds receiving virus by the respiratory route, an inhaled dose of 3715 MICLD 50 units presented in one minute resulted in both viremic and serologic response in 60 to 80 percent of the birds. The birds did not respond to a subsequent challenge by the respiratory route, indicating a high level of immunity to VEE virus infection. Birds receiving virus by subcutaneous injection responded identically to the respiratory group in terms of level and duration of viremia and serum neutralizing antibodies. Responses after injection, however, occurred in 100 percent of the birds; viremias first appeared on day 1 after infection as opposed to viremias first occurring on days 1 or 2 in the respiratory group. Serum neutralizing titers in both groups of birds were followed for 112 days after exposure to or injection of virus.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1965
- Accession Number
- AD0475556
Entities
People
- William S. Miller
Organizations
- United States Army Biological Warfare Laboratories