ORAL LIVE TULAREMIA VACCINE
Abstract
Previously reported data on the pathogenesis and immunogenicity of live vaccine strain LVS have been sufficiently encouraging to warrant an evaluation of oral vaccination with this strain. A group of eight monkeys were administered strain LVS dermally by acupuncture. Both the oral and the dermal inocula of LVS proved innocuous but 13 of the 16 animals that received strain 425 showed a transient low-grade febrile reaction. An agglutinin response was obtained in all vaccinees. Approximately 10 weeks after vaccination, these animals and a group of seven unvaccinated controls inhaled 10,000 organisms of strain SCHU. All animals became infected but 64 to 71% of the vaccinees survived in contrast to 14% of the controls. These studies indicate a potential for oral immunization with live tularemia vaccine prepared from strain LVS.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1965
- Accession Number
- AD0476499
Entities
People
- Henry T. Eigelsbach
- Jerry J. Tulis
- Richard B. Hornick
Organizations
- United States Army Biological Warfare Laboratories