PRELIMINARY STUDIES ON THE DISAPPEARANCE OF BOTULINUM TOXIN FROM THE CIRCULATING BLOOD OF RHESUS MONKEYS

Abstract

Rhesus monkeys (including two survivors of previous exposures to botulinum toxin) were given Type A botulinum toxin intravenously, and disappearance of the toxin from the serum was measured. These animals were given about 95 LD50's and died while there was still from 30% to 60% of the dose in the serum. Hematocrit values dropped much more swiftly and farther than did those of a control monkey bled on the same schedule.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1965
Accession Number
AD0477172

Entities

People

  • C. S. Streett
  • Duane F. Ford
  • James L. Stookey

Organizations

  • Edgewood Chemical Biological Center

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Animals
  • Bioassay
  • Biomedical Research
  • Blood
  • Blood Cells
  • Blood Serum
  • Blood Volume
  • Cells
  • Dilution
  • Hematocrit
  • Laboratory Animals
  • Lethal Dosage
  • Monkeys
  • Rhesus Monkeys
  • Veins
  • Volume

Fields of Study

  • Biology
  • Psychology

Readers

  • Educational Psychology
  • Immunology