STUDIES ON EXPERIMENTAL SHIGELLOSIS: SPECIAL REFERENCE TO SPECIAL CHARACTERISTICS OF SHIGELLA SPECIES AND THEIR ACTION UPON LIGATED LOOP
Abstract
The serological, biochemical and enzymic specificities of shigella associated with virulence were sought after in conjunction with the ability to induce changes in the ligated intestinal loop of rabbits. The lactose or sucrose positive shigella were isolated from patients and the correlation of the ability to ferment lactose and sucrose and the ability to induce changes in the loop were examined. The ability to ferment lactose seems to be associated with virulence but antigens seems more closely associated with virulence. The ability to be agglutinated by acid which was said to be associated with virulence was not associated with the ability to induce changes. The pathological changes were not associated with the number of shigella recovered after 24 hours of inoculation, if the number exceeded 108. Shigella was mutated to non-virulent mutants several hours after inoculation and some shigella recombined with residential organisms and became lactose positive or shigella without shigella antigens. These organisms had weaker ability to induce changes. But on the other hand, there were residential organisms which enhanced the pathological changes in the loop.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 02, 1965
- Accession Number
- AD0480168
Entities
People
- Akira Ghoda