STUDIES ON THE ANTIVIRAL ACTIVITY OF GUANYLHYDRAZONES ESPECIALLY AGAINST ARBO- AND MYXOVIRUSES

Abstract

Two hundred and sixty-five chemical compounds, guanylhydrazones, azlactones, hydrazones, phenols, carbonyl compounds and miscellaneous ones were tested for in vitro antiviral activity against influenza virus. One hundred and four out of two hundred and sixty-five compounds were completely inhibitory by the screening test. Selected 89 compounds were qualitatively analyzed for the antiviral and toxic activities. Fourteen out of eighty-nine compounds were found to be inhibitory with the ratio of 4 on more of non-toxic concentration versus minimal inhibitory concentration. One compound, serial number 212, synthesis number 178 inhibited HA production with a final concentration of 1.6 gamma/cc and was toxic with a final concentration of 25 gamma/cc.

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Document Details

Document Type
Technical Report
Publication Date
Feb 28, 1966
Accession Number
AD0480196

Entities

People

  • Daizo Nagaki

Tags

DTIC Thesaurus Topics

  • Animal Diseases
  • Chemical Compounds
  • Chemistry
  • Classification
  • Contracts
  • Diseases And Disorders
  • Hydrazines
  • Influenza
  • Microorganisms
  • Organic Chemistry
  • Organic Compounds
  • Plastic Explosives
  • Production
  • Security
  • Toxicity
  • Universities
  • Viruses

Readers

  • Analytical Chemistry
  • Mathematics or Statistics
  • Virology (or Medical Virology).