METABOLISM OF RICKETTSIAE AND RELATED MICROORGANISMS
Abstract
The pathway of glutamine utilization was investigated by thin layer chromatography. The accumulation of intermediates of the citric acid cycle from alpha-ketoglutarate to malate was demonstrated by incubating the microorganisms with small amounts of glutamine, labeled with 14C to a high degree of specificity, and large amounts of unlabeled intermediates. It was not possible, however, to demonstrate the accumulation of oxaloacetate or the tricarboxylic acids. The latter results can be attributed to the instability of oxaloacetate and the impermeability of the microorganisms to citrate.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 31, 1965
- Accession Number
- AD0481056
Entities
People
- Emilio Weiss
Organizations
- Naval Medical Research Center