PRECIPITIN AND NEUTRALIZING ANTIBODY RESPONSE ELICITED BY CROTALUS ATROX VENOM ANTIVENOM PRECIPITATE

Abstract

Rabbits immunized with insoluble C. atrox venom-antivenom precipitate produced less precipitins and nearly as much neutralizing antibody as those injected with whole venom. The data show that venom neutralizing antibodies are precipitins and that the apparent non-relationship between precipitin titer and antitoxic value is due to the polyvalency of venom-antivenom systems. The value of using insoluble antigen-antibody precipitates to isolate specific antigens, from a mixture, for immunization is pointed out.

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Document Details

Document Type
Technical Report
Publication Date
Nov 30, 1965
Accession Number
AD0481118

Entities

People

  • Anthony J. Luzzio
  • Gilberto S. Trevino

Organizations

  • United States Army Medical Research Laboratory

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Animals
  • Antibodies
  • Antigen-Antibody Complex
  • Antigens
  • Biological Laboratories
  • Biomedical Research
  • Classification
  • Contractors
  • Contracts
  • Data Processing
  • Governments
  • Immunity
  • Immunization
  • Laboratory Animals
  • United States
  • United States Government

Fields of Study

  • Biology

Readers

  • Immunology
  • Superconducting Magnet Technology