GROUP C ARBOVIRUS INFECTIONS IN RHESUS MONKEYS

Abstract

Macaca mulatta were found to be susceptible to infections with group C arboviruses following subcutaneous inoculation. Infections engendered by Oriboca, Marituba, Murutucu, and Apeu viruses were consistent in time of onset, duration, and level of viremia. The appearance of viremias with Itaqui virus was occasionally inconsistent and with Caraparu virus the appearance of viremias was very irregular. Overt signs of systemic illness in monkeys infected with any of the group C viruses used were limited to fevers, which were detected in only a few animals. Infections with these viruses appeared to be noncontagious for uninoculated monkeys that were exposed by limited contact to infected monkeys in the viremic phase. Cross-immunity was demonstrated by monkeys that recovered from one virus infection and challenged with related heterotypic viruses.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 1966
Accession Number
AD0482567

Entities

People

  • Eugene R. Borman
  • Stefan G. Belman
  • William P. Allen

Tags

DTIC Thesaurus Topics

  • Adaptive Immunity
  • Animals
  • Antibodies
  • Arbovirus Infections
  • Arboviruses
  • Environment
  • Immunity
  • Infection
  • Inoculation
  • Lethal Dosage
  • Monkeys
  • Resistance
  • Rhesus Monkeys
  • United States
  • Virus Diseases
  • Viruses
  • Wound Infections

Fields of Study

  • Biology

Readers

  • Toxicology/Environmental Toxicology
  • Virology (or Medical Virology).