STUDIES ON THE PATHOGENICITY AND RELATED CHARACTERISTICS OF BARTONELLA BACILLIFORMIS
Abstract
The genus Bartonella was re-evaluated in terms of characterization and identification. Effort included investigation of serological procedures (fluorescent antibody, immuno-diffusion, and hemagglutination techniques) and morphological, biochemical, and cultural studies. Results obtained explained the lack of universally accepted properties of the organism. Investigations of pathogenicity were directed towards (1) reproducing the various forms of Bartonellosis in various animal species and (2) determining the relative susceptibilities or resistances of the animal species to the organism. The rabbit proved more susceptible than the Rhesus monkey, guinea pig, suckling mouse, or hamster when the intravenous, subcutaneous, intraperitoneal, and intratesticular routes of inoculation were employed. A distinct alteration of the rabbit's normally operative hemopoietic system could be induced. However, a distinct anemia and/or an asymptomatic infectious process could be induced, presumably due to the comparatively high, specific resistance of the animal. Boiled cell suspensions of the organism sensitized the rabbit to such a degree that anaphylactic shock could be provoked.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1966
- Accession Number
- AD0484102
Entities
People
- Bonita Baumann
- John M. Slack
- Paul D. Mitchell
Organizations
- West Virginia University