SCREENING METHOD FOR THE DETERMINATION OF IRRITATING PROPERTIES OF AIRBORNE MATERIALS TO THE UPPER RESPIRATORY TRACT. PLETHYSMOGRAPHIC METHOD IN MICE,
Abstract
Ascreening method for irritants based upon the reflex-induced decrease in respiratory rate of animals during exposure to chemical irritants has been developed. From the data presented and comparison with other methods, it was concluded that: (1) the method permits the recognition of the irritating effects of substances to the upper respiratory tract; (2) the method is simple enough to permit its use in a screening program; (3) the results are reproducible; (4) dose-response curves and minimum effective doses can be determined; (5) the method is sensitive enough to detect irritating effects at low exposure concentrations where no pathological modifications occur. During the last two years, over 2,000 compounds from several chemical classes have been investigated. The method has been found to be reliable and useful in recognizing irritating compounds and for extrapolation of the data to possible reactions in humans.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1966
- Accession Number
- AD0484247
Entities
People
- Yves Alarie