Excretion of Water and Electrolytes During the Osmotic Diuresis of Dogs with Experimental Diabetes Insipidus,
Abstract
Diabetes insipidus dogs required as much as 2 times the normal volume of urinary water for excretion of a given solute load. The reproducible relation of rates of excretion of sodium, potassium and mannitol to that of total solute excretion indicated that the percent distribution of urinary solutes in dogs with diabetes insipidus during mannitol loading was the same as that of normal dogs. The bulk of urinary water loss, 75-85%, after mannitol loading in the diabetes insipidus dog originated from an excessive egress of 'solute-free' water from the cellular compartments. Extracellular fluid (calculated from the volume of isotonic urinary sodium) accounted for but 10-23% of total urine water, compared to the normal values of 30-55%.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 13, 1952
- Accession Number
- AD0495831
Entities
People
- Abner H. Levkoff
- William A. Brodsky
Organizations
- University of Louisville