SCREENING OF POTENTIAL RADIO-PROTECTIVE COMPOUNDS IN MICE.
Abstract
A total of 701 coded compounds were screened for their potential radio-protective potency in mice in accordance with the following method: (1) An approximate maximum tolerated dose of each coded test compound was determined by administering the compound intraperitoneally in graded doses to groups of mice and these mice observed for pharmacologic and toxicologic signs. Survivors at seven days were subjected to gross necropsy, also. (2) The test compound at this dose was then administered intraperitoneally to groups of six mice. At an interval when the compound was estimated to be most pharmacologically active, these mice were exposed to radiation from a Maxitron 300 X-ray unit at a dose which was calculated to be the LD 100/30 in similar groups of untreated animals. Untreated animals were exposed to this dose of radiation at the same time thereby serving as controls. The estimated protection offered by administration of the test compound was then determined, as compared with control values, and tabulated. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- May 12, 1964
- Accession Number
- AD0600228
Entities
People
- Geoffrey Woodard