PULMONARY VENTILATION AND DIFFUSION IN SHOCK
Abstract
Injection of endotoxin in dogs resulted in a sudden fall in compliance and a rise in resistance to airflow immediately following injection. These changes were transitory and less constant in animals which were heparinized. Further studies of pulmonary diffusion in dogs confirmed the fall in the diffusion capacity for carbon monoxide (DLCO) and in lung capillary blood volume (Vc) during both acute and irreversible shock. The fall in DLCO was always proportional to the volume of red blood cells in the lung capillaries (Vrbc). The fall in Vc was not related to the duration of the anesthesia nor to the retransfusion of blood. Control studies were carried out as a preliminary to the evaluation of patients in shock.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1964
- Accession Number
- AD0601939
Entities
People
- Denise Jouasset-strieder
- Edward A. Gaensler
- John J. Byrne
- John J. Cahill
Organizations
- Boston University