MOLECULAR STRUCTURE AND DIFFUSIONAL PROCESSES ACROSS INTACT EPIDERMIS.
Abstract
The permeabilities of the homologous series of straight chain alcohols C1 - C8 through human epidermal membranes were investigated. In this series a smooth decrease in the polar character of the molecules occurs. (Since the molecular volume increases only by approximately a factor of four within the series; the effect of increasing molecular size on the diffusion rate is negligible i.e. approx. 1.6). Permeability constants were obtained for each alcohol as a function of temperature (0 - 60C) and activation energies were computed. Permeability constants were compared with olive oil-water partition coefficients and with stratum corneum-water partition coefficients. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1964
- Accession Number
- AD0603244
Entities
People
- Robert J. Scheuplein
Organizations
- Harvard Medical School