NEW METHODS DEVELOPMENT FOR IRRITANT SCREENING

Abstract

Rabbit aorta and guinea pig ileum were evaluated to determine their suitability as biological indicators of irritant action. The effects of irritants on incised aortic and ileac tissue indicate that it is not advisable to further consider them as biological indicators. Cats and monkeys are now being evaluated for irritant screening. Too, a study is being made of a crude aerosol exposure technique.

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Document Details

Document Type
Technical Report
Publication Date
Aug 05, 1964
Accession Number
AD0603789

Entities

People

  • E. R. Hart

Tags

DTIC Thesaurus Topics

  • Animals
  • Arteries
  • Body Weight
  • Connective Tissue
  • Contracts
  • Experimental Design
  • Histamine
  • Indicators
  • Irritants
  • Lagomorphs
  • Medical Personnel
  • Polyethylene Glycols
  • Rodents
  • Smooth Muscle
  • Surveys
  • Tissues
  • Veterinary Medicine

Fields of Study

  • Medicine

Readers

  • Systems Analysis and Design
  • Toxicology/Environmental Toxicology