GENETIC REPLICATION AND MACROMOLECULAR SYNTHESES IN TEMPERATE BACTERIOPHAGES.
Abstract
Experiments involving mixed superinfection of lysogenic bacteria with an homologous phage and an immunityinsensitive mutant show that the repressor of immunity blocks altogether transcription and replication directly. A new method allows (a) preferential isolation of those conditional defective mutations which affect early functions and (b) isolation of sus mutants which are well corrected by bacterial suppressors. There is direct evidence for Spotts and Stanier's hypothesis that the bacterial gene controlling the response to streptomycin is involved in the determination of the structure of ribosomes. Many streptomycin-resistant mutants (which are now known to be altered in the structure of their ribosomes) behave much as pleiotropic suppressors. The exact structure of ribosomes probably contributes to the specificity of the translation process.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1964
- Accession Number
- AD0608793
Entities
People
- Rintu Thomas