CUTANEOUS TOXICITY EVALUATION OF AIR FORCE DEVELOPMENT MATERIALS-VII

Abstract

Five Air Force development materials were studied via the prophetic patch test method on laboratory animals to determine the primary irritant effect, gross sensitization index, and gross percutaneous toxicity of these materials. The patch test studies with rabbits indicated that two of the materials produced severe primary irritant action. A third material produced primary irritation whose severity was not considered sufficient to preclude testing in humans. Testing on human volunteers was therefore carried out with three of the materials. Results indicated that only one of these materials was safe to use in contact with human skin.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1964
Accession Number
AD0610520

Entities

People

  • Morris V. Shelanski

Tags

Communities of Interest

  • Biomedical
  • Weapons Technologies

DTIC Thesaurus Topics

  • Abstracts
  • Air Force
  • Air Force Personnel
  • Biomedical Research
  • Chemical Compounds
  • Contractors
  • Contracts
  • Government Procurement
  • Governments
  • Irritation
  • Laboratory Animals
  • Lubricating Oils
  • Materials
  • Medical Laboratories
  • Test Methods
  • Toxicity
  • Weapons

Readers

  • Polymer Science and Engineering.
  • Toxicology/Environmental Toxicology