INFLUENCE OF CORTISONE ON GLYCONEOGENESIS, ENDOTOXIN LETHALITY AND TRYPTOPHAN PYRROLASE INDUCTION IN COLD-EXPOSED MICE
Abstract
Mice singly housed and exposed to 5C are almost as responsive as animals at 25C in carrying out glyconeogenesis following a single injection of cortisone. An LD50 of endotoxin lowers liver glycogen about equally in mice housed at each of the two temperatures, but the dose for mice at 5C is one one- hundredth the dose at 25C. Cortisone given concurrently with the endotoxin prevents glycogen depletion in mice at 25C but not in those housed at 5C, except possibly at certain critical doses. Cortisone also fails to induce an increase in liver tryptophan pyrrolase activity in cold-exposed mice, in contract to those maintained at room temperature, and this failure cannot be ascribed to any alteration in hematin level, the cofactor for the enzyme. These findings are considered as evidence for an impaired capacity for protein (enzyme) synthesis in normothermic animals during acute exposure to cold.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1964
- Accession Number
- AD0610644
Entities
People
- L. Joe Berry
Organizations
- Bryn Mawr College