CHANGES IN WATER-SALT EXCHANGE IN RADIOPHOSPHORUS-INDUCED RADIATION SICKNESS IN RABBITS,
Abstract
In acute radiation sickness induced by subcutaneous injection of P32 in a lethal dosage (2.5 microcuries/gram), there was observed in the majority of rabbits during the first one or two days, an increased elimination of water in the urine, with no change of water intake. During the subsequent few days, urination fell below the original figures, after which it again gradually increased and reached a maximum three to five days before the death of the animals. During the last days of life, diuresis sharply decreased to figures below initial levels. In some cases there was anuria. On several days during the radiation sickness, the content of water in the rabbits' blood serum increased by 0.6 to 3.6% as compared with initial levels. More significant was the 0.5 to 8.5% increase of water in the whole blood as compared with the initial levels. In the majority of the rabbits, during the period of radiation sickness, the content of chlorides in the blood plasma and of calcium in the blood serum fell to amounts below initial levels. It was noted that the amount of chlorides in the urine decreased as compared with initial levels. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1960
- Accession Number
- AD0610886
Entities
People
- M. A. Khvoinitskaya