HYPOTHALAMIC SECRETORY FACTOR FOR ADRENOCORTICOTROPIC HORMONE (SF-ACTH).

Abstract

The purpose of this research is to purify the hypothalamic hormone responsible for the increased biosynthesis and secretion of ACTH in stress. This hormone, originally named 'corticotropin releasing factor (CRF)' by Dr. Murray Saffran of McGill University, is now referred to as 'hypothalamic secretory factor for ACTH (HSF-ACTH)'. Because the only feasible guide to yield and specific activity of HSF-ACTH is a rather complicated biological assay system, the studies have included ways to improve and simplify the biological assay for the hypothalamic secretory factor for ACTH are based on a discovery that in the rat anesthetized with pentobarbital, morphine inhibits ACTH secretion to nonspecific stimuli without intererfering with the action of HSF-ACTH on the anterior pituitary gland.

Document Details

Document Type
Technical Report
Publication Date
Jan 15, 1965
Accession Number
AD0611179

Entities

People

  • Paul L. Munson

Organizations

  • Harvard College

Tags

DTIC Thesaurus Topics

  • Assays
  • Bioassay
  • Endocrine Glands
  • Hormones
  • Pituitary And Hypothalamic Hormones And Analogues
  • Pituitary Glands
  • Secretion

Readers

  • Cardiovascular Physiology
  • Molecular and Cellular Biochemistry
  • Systems Analysis and Design