SOME BIOCHEMICAL EFFECTS OF BETA-MERCAPTOETHANOL ON THE LIVER OF MICE AND RATS (QUELQUES EFFETS BIOCHIMIQUES DU BETA-MERCAPTOETHANOL SUR LE FOIE DE SOURIS ET DE RAT),

Abstract

The effects of beta-mercaptoethanol (HSCH2-CH2OH) on the biochemistry of mouse and rat liver were studied both in vivo and in vitro. The intra-peritoneal injection of mercaptoethanol has no appreciable effect on the soluble -SH, ATP, DNA, and RNA content of the cells. Mercaptoethanol exerts a very definite inhibitory effect on the incorporation of labeled amino acids into liver proteins both in vivo and in vitro (30-40% inhibition). Mercaptoethanol, if injected in vivo, does not set free one of the enzymes characteristic of lysosomes, acid phosphatase; there is no liberation of acid phosphatase when a particulate fraction containing the lysosomes is treated by mercaptoethanol in vitro. (Author)

Document Details

Document Type
Technical Report
Publication Date
Jan 20, 1961
Accession Number
AD0611502

Entities

People

  • J. Brachet
  • M. Cape
  • M. Decroly
  • N. Six

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Biochemistry
  • Biological Sciences
  • Cells
  • Chemical Compounds
  • Chemistry
  • Inhibition
  • Lysosomes
  • Netherlands
  • Particulates

Fields of Study

  • Biology

Readers

  • Molecular and Cellular Biology
  • Oncology (Cancer Research).
  • Small Business Innovation Research Program (SBIR) EDI Research and Innovation.