STUDY OF THE PHYSIOLOGICAL CHEMICAL MECHANISMS OF THE TOXIC ACTION OF HYDRAZINES.

Abstract

The first four months of work have established procedures and also for the rat (1) provided symptomological evidence that hydrazine has a different mode of action from unsymmetrical dimethylhydrazine (UDMH) or monomethylhydrazine, (2) established LD50's with and without pyridoxine, (3) shown that UDMH and hydrazine stimulate respiration and inhibit glycolysis when brain slices from normal and poisoned rats are compared, (4) shown a profound (e.g. 95%) reduction in brain lactate by UDMH and hydrazine.

Document Details

Document Type
Technical Report
Publication Date
Dec 31, 1962
Accession Number
AD0611761

Entities

People

  • R. D. O'brien

Organizations

  • Cornell University

Tags

DTIC Thesaurus Topics

  • Aliphatic Compounds
  • Chemical Compounds
  • Dimethylhydrazines
  • Glycolysis
  • Hydrazine Derivatives
  • Hydrazines
  • Methyl Hydrazines
  • Organic Compounds
  • Pyridoxines
  • Respiration
  • Toxic Actions

Readers

  • Molecular and Cellular Biology
  • Toxicology/Environmental Toxicology
  • Underwater engineering and Marine Technology.