EFFECT OF EGG YOLK AND PHOSPHATIDES ON ANTHRAX INFECTION OF RATS AND GUINEA PIGS

Abstract

Suspension of anthrax spores or vegetative cells in phosphatidyl ethanolamine, or the related phosphatides, phosphatidyl serine and phosphatidyl inositol, markedly reduced the intraperitoneal median lethal dose for guinea pigs and Sprague-Dawley rats, thus duplicating the effect of whole chicken egg yolk. Quantitative considerations indicated that the amount of phosphatidyl ethanolamine present in yolk could account for the effect of yolk. Lecithin, the other major phosphatide of yolk, was ineffective. Phosphatidyl ethanolamine appeared to influence the initial phases of host-bacterium interaction.

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Document Details

Document Type
Technical Report
Publication Date
Sep 02, 1964
Accession Number
AD0611972

Entities

People

  • Ralph W. Kuehne
  • William D. Sawyer
  • Williams. Gochenour Jr.

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Alcohols
  • Cells
  • Ethanolamine
  • Hard Copy
  • Infection
  • Lethal Dosage
  • New York
  • Plant Extracts
  • Rodents
  • Sugar Alcohols
  • Systems Biology
  • Wound Infections

Fields of Study

  • Biology
  • Chemistry

Readers

  • Molecular and Cellular Biochemistry
  • Toxicology/Environmental Toxicology