PROMOTION OR RETARDATION OF THE GROWTH OF ADENINE AUXOTROPHS OF CANDIDA ALBICANS BY PURINES, PYRIMIDINES AND NUCLEOSIDES,

Abstract

A study has been made of the growth responses to purine and pyrimidine metabolites shown by sixteen ultraviolet-induced adenine requiring mutants of Candida albicans blocked at early stages in purine biosynthesis. The salient findings establish that, in C. albicans, (1) the pathway for the conversion of adenine to guanine is not reversible, (2) exogenous nucleotides are not utilized, and the purine and pyrimidine components of exogenous nucleosides must be converted to the free base form before utilization and (3) cytosine and guanine competitively inhibit different steps in the utilization of exogenous adenine. (Author)

Document Details

Document Type
Technical Report
Publication Date
Apr 27, 1964
Accession Number
AD0612554

Entities

People

  • A. Sarachek

Organizations

  • Wichita State University

Tags

DTIC Thesaurus Topics

  • Anabolism
  • Chemical Compounds
  • Conversion
  • Cytosine
  • Metabolites
  • Microbiology
  • Netherlands
  • Nucleosides
  • Nucleotides
  • Organic Compounds
  • Pyrimidines
  • Retardation
  • Reversible
  • Serology

Readers

  • Molecular and Cellular Biochemistry
  • Parasitology and Pharmacology of Malaria.