ACUTE TOXICITY STUDIES ON ETHANOL, PROPANOL, AND BUTANOL,
Abstract
Three series of 10 dogs each were used to study the effects of intravenously administered ethanol, propanol-1, and butanol-1. In normothermic dogs, with supported respiration and nitrous oxide anaesthesia (after induction), the mean lethal doses for ethanol, propanol-1, and butanol-1 were 4.90, 2.42, and 1.26 g/kg respectively. At a constant infusion rate, the blood alcohol levels increased almost linearly with time. Relationships between ethanol, propanol-1, and butanol-1 blood levels and blood pressure, pulse, and electrocardiogram were established. Two minutes cardiac standstill occurred at the following blood levels: ethanol, 1499 mg/100 ml; propanol-1, 713 mg/100 ml; butanol-1, 279 mg/100 ml. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 27, 1964
- Accession Number
- AD0613108
Entities
People
- D. C. Macgregor
- E. Schonbaum
- W. G. Bigelow
Organizations
- University of Toronto