THE METABOLISM OF SIMPLE CARBON COMPOUNDS IN MICRO-ORGANISMS.
Abstract
This report summarizes the evidence for the views that (a) the structural gene for citrate synthase adjoins that for galactokinase on the chromosome of E. coli; (b) the anaplerotic carboxylation of C3-acids in E. coli is effected via phosphopyruvate carboxylase; this reaction is regulated by acetyl-coenzyme A; (c) the functioning of isocitrate lyase is causally related to growth on acetate; (d) the activation of an L-serine dehydratase by its substrate is associated with a change in the molecular weight of the enzyme; (e) erythro beta-Hydroxyaspartate dehydratase, highly purified, differs from other hydroxyaminoacid dehydratases; (f) P. ovalis Chester contains a highly active oxaloacetate 4-carboxylyase, which is inhibited by acetyl-coenzyme A derivatives; (g) Cl. kluyveri extracts catalyse the ferredoxin-dependent carboxylation of acetyl-coenzyme A. In addition, a number of matters relevant to these major areas of work are discussed. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1965
- Accession Number
- AD0614479
Entities
People
- H. L. Kornberg
Organizations
- University of Leicester