EFFECT OF CARBON DIOXIDE EXPOSURE ON ELECTROLYTE DISTRIBUTION AND ITS RELATIONSHIP TO CONVULSIVE ACTIVITY IN RATS,
Abstract
The effect of exposure of rats to 35% CO2 - 65% 02 for periods of 5, 7, 10, 15, and 30 minutes and of recovery for 30 and 60 minutes after 30 minute exposure on electrolyte distribution and its relationship to seizure activity in unanesthetized rats was studied. Significant changes were observed 5 min. after exposure and 30 min. after recovery. Seizure activity was observed in about 50% of the exposed rats after 2-10 min. exposure and lasted about 5 sec. The recovery seizure, through rarer, came sooner, lasted longer, and was more violent; only about 5% of the exposed rats displayed a withdrawal seizure, 1/2 to 1 and 1/2 min. after withdrawal. With CO2 exposure, there were increases of Na and water and decreases of K and Cl in plasma in unanesthetized rats. There were decreases of K, Na and Cl in cerebral cortex. With withdrawal in air and relative to the exposure period, the changes were all reversed, with the exception of cortex Cl which continued to drop during withdrawal. Like systemic stress, severe physical stress (blow on the head) may have increased plasma K (5.63 mEg/L) while in rats anesthetized with Na pentobarbital the average plasma K value was 4.2 mEg/L. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 30, 1965
- Accession Number
- AD0615298
Entities
People
- H. W. Gillen
- P. T. Hsu Cheng
Organizations
- University at Buffalo