STUDIES OF BURN SKIN PROTEIN IMMUNOELECTROPHORETIC ANALYSIS OF PROTEINS EXTRACTED FROM BURNED SKIN,
Abstract
The manifest seriousness of deep thermal skin injuries and the possible noxious effects of the injuried tissue upon the patient indicate the need to obtain more information concerning changes in the burn skin. In this study sequential biopsies were taken from third degree burn wounds, and the proteins were extracted with saline solution. Immunoelectrophoretic techniques were used to identify the proteins that could be extracted from these biopsies and from samples of normal skin. Three burned patients and 6 normal were studied. The amounts of extractable 7 S globulin, transferrin, ceruloplasmin, alpha 1-glycoprotein, and albumin increased following the burn injury. There was little or no change in prealbumin, orosomucoid, Beta 1 lipoprotein, or fibrinogen. The proteins showing the greatest increase were those related to antibody formation or those with a 'binding' function. The possible significance of these is discussed. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1965
- Accession Number
- AD0615485
Entities
People
- M. S. Rittenbury
Organizations
- Virginia Commonwealth University School of Medicine